It is well known that the major biologic function of vitamin D is to maintain normal blood levels of calcium and phosphorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. Recent data have also linked low vitamin D levels to a wide range of diseases, including cancer, cardiovascular disease and autoimmune diseases.

Previous research has indicated that adequate levels of vitamin D should be maintained for the prevention and treatment of various diseases. Vitamin D supplementation is the best method to optimize vitamin D levels. A recent study on breast cancer patients has suggested that high dose vitamin D supplements are better than those providing a low dose of vitamin D.

This retrospective study involved 224 women diagnosed with stage 0-III breast cancer.  Vitamin D deficiency and insufficiency were quite common in this population (66.5%), and supplementation with vitamin D was associated with significant increases in 25(OH)D levels.

Subjects received either no vitamin D supplementation; “low dose” supplementation, consisting of 1,000 IU/d vitamin D; or “high-dose” supplementation, consisting of at least 50,000 IU/d vitamin D. 25(OH)D was reassessed in the following 8-16 weeks.

High dose supplementation was associated with significantly increased 25(OH)D levels, while low-dose supplementation did not significantly increase those levels. Low vitamin D status was associated with reduced BMD in the spine.

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Source:
Breast cancer research and treatment

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A recently published study has shown that the women suffering with rheumatoid arthritis (RA) have a tougher time conceiving compared to women without the disease.

In this study of more than 68,000 pregnant women, the researchers found that 25% of women with RA (onset prior to conception) were more likely to have taken longer than 12 months to conceive, whereas only 16% of women without the disease had needed that much time. Moreover, 10% of the women with RA had been treated for infertility, compared with less than 8% of other women without RA.

However, it is not clear that whether the disease or its medications affect a woman’s ability to conceive, the study shows a slight reduction in the fertility in women with RA as compared to those who did not have RA.

Rheumatoid arthritis is an autoimmune disease, in which the body’s own immune system mistakenly attacks tissue in the joints, leading to inflammation, pain and progressive joint damage.

Previous studies have shown that vitamin D is a powerful immune-modulator. Higher intake of vitamin D is inversely associated with a higher risk of developing RA. Read more about the benefits of vitamin D in rheumatoid arthritis here.

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Source:
Arthritis and rheumatism

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Onset of type 2 diabetes happens gradually. When the process begins, there is often time to reverse the metabolic changes through lifestyle. Well known risk factors for diabetes are obesity, sedentary lifestyle and genetic predisposition. Now, the researchers have found that measuring five amino acids in the blood can also help identify patients, at high risk of developing type-2 diabetes.

For the study, researchers tracked 2,400 participants for a period of 12 years. They took blood samples at the beginning of the investigation and continued to examine individuals’ medical records. The results showed that participants who had higher levels of the amino acids isoleucine, leucine, valine, tyrosine and phenylalanine were significantly more likely to develop type 2 diabetes.

The study concludes that these findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment.

Previous research has also linked the prevalence of type-2 diabetes with vitamin D deficiency. Various studies have suggested that the optimal levels of vitamin D can protect you from diabetes if you are at a high risk of developing the disease in the recent future. Moreover, studies also provide evidence that vitamin D supplementation is also helpful in reducing the amount of insulin in patients with insulin dependent type 2 diabetes.

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Source:
Nature medicine

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In the previous blog, you read about the prevalence of vitamin D deficiency in patients with chronic liver disease. Whether this association is causal or correlative is not yet clear. However, it is clear that these patients require vitamin D supplementation. It has been demonstrated that vitamin D supplements are effective in patients with chronic liver disease.

A recently published study prospectively examined the prevalence of vitamin D deficiency and the response to replacement in patients with chronic liver disease. One hundred and fifty-eight patients with chronic liver disease were enrolled. Serum 25-hydroxyvitamin D (25[OH]D) levels were classified as: severely deficient less than 25 nmol/l, deficient 25-54 nmol/l or replete greater than 54 nmol/l. Sixty-five of 158 (41%) had cirrhosis.

The researchers found that all patients were vitamin D deficient and among those 15% were severely deficient. After vitamin D replacement, the researchers noted a 60% rise in vitamin D levels of patients with deficiency. On the other hand, the levels decreased by 25% in non-treated initially replete patients over a period of 4 months.

The study concluded that vitamin D deficiency improves with oral vitamin D supplementation and levels fall without supplementation.

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Source:
http://www.ncbi.nlm.nih.gov/pubmed/20801590

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We are aware of the prevalence of vitamin D deficiency all over the world, irrespective of the availability of sunshine. Vitamin D deficiency has been associated with a number of diseases like cancer, arthritis, asthma and cardiovascular diseases. There has been some evidence that suggest that vitamin D deficiency is also related to liver health.

In the recent past, a study was done to determine the prevalence of vitamin D deficiency in patients with chronic liver disease. The results found were surprising. Let’s see………

The investigators looked at the vitamin D levels of 118 patients with chronic liver disease (43 with hepatitis C cirrhosis, 57 with hepatitis C but no cirrhosis, 18 with non-hepatitis C-related cirrhosis). Severity of vitamin D deficiency was graded as mild (20-32 ng/ml), moderate (7-19 ng/ml) or severe (<7 ng/ml), normal being >32 ng/ml.

Most patients (92.4%) were found to have some degree of vitamin D deficiency. In the group with cirrhosis 16.3% had mild, 48.8% had moderate, and 30.2% had severe vitamin D deficiency. In the group with no cirrhosis, 22.8% had mild, 52.6% had moderate, and 14% had severe vitamin D deficiency. In the group of those with cirrhosis (but not hepatitis C) 38.9% had mild, 27.8% had moderate, and 27.8% had severe vitamin D deficiency. Patients with cirrhosis were more likely to have severe vitamin D deficiency (<7 ng/ml) than in those who did not have cirrhosis—29.5% versus 14.1%.

The study concluded that vitamin D is universally deficient among patients with chronic liver disease, and at least one-third of them suffer from severe vitamin D deficiency.

Vitamin D supplements are also effective in resolving vitamin D deficiency in people with chronic liver disease. Watch for our future posts to know more about this.

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Source:
Digestive diseases and sciences

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Chronic constipation is a common, frustrating digestive problem not only in adults, but also in children. It causes distress to both the child and the family, and may result in severe emotional disturbance. Recently, a new study found out that probiotic with a specific strain is effective in the treatment of childhood constipation.

The research, published in Nutrition Journal, showed that intake of Bifidobacterium breve over four weeks significantly increased the defecation frequency, consistency, and reduced abdominal pain.

Twenty children of age 3 to 16 years were included in the study and were given one sachet of powder daily, containing 108- 1010 CFU Bifidobacterium breve.

After four weeks, the investigators noted a significant increase in the defecation frequency and stool consistency. On the other hand, there was a significant decrease in the number of fecal incontinence episodes and abdominal pain episodes per week.

The study suggests that probiotics provide positive results in alleviating the symptoms of childhood constipation.

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Source:
Nutrition Journal

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If you have gone through my article “Role of probiotics in H.pylori infections”, you may know that H. pylori infection is considered one of the major risk factors underlying the development of gastritis and gastric and duodenal ulcers. The use of probiotics is a potentially promising tool to prevent H. pylori.

Spanish scientists have now identified a strain of probiotic bacteria that may be useful in treating ulcers caused by H.pylori.

In this study, the researchers tested numerous strains of Bifidobacteria isolated from the feces of breast-fed infants for activity against H pylori. They identified one strain (Bifidobacterium bifidum CECT 7366) that under certain conditions had an inhibition level of nearly 95 percent in vitro and tested its activity against infection in mice.

After 21 days, it was found that the mice treated with this probiotic strain developed significantly less ulcers than the control group. These results demonstrate that Bifidobacterium bifidum CECT 7366 can be considered a probiotic able to inhibit H. pylori.

Not only H.pylori, but probiotics are also being used to treat or prevent a broad range of human diseases, conditions, and syndromes like food allergy, lactose intolerance, yeast infections and inflammatory bowel diseases.

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Source:
http://www.ncbi.nlm.nih.gov/pubmed/21169430

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During or after chemotherapy, most cancer patients suffer various side-effects which decrease their quality of life. One of these common side-effects is fatigue and weight loss. These side-effects often discourage cancer patients. Researchers have now found a new hope to prevent this deterioration. It is fish oil supplements.

A recent study has found that fish oil supplements may help prevent muscle and weight loss that commonly occurs in cancer patients undergoing chemotherapy.

For the study, the researchers reviewed 40 patients newly diagnosed with non-small-cell lung cancer. Sixteen patients were given 2.2 grams of fish oil per day, while the remaining patients received standard care.

The researchers found that about 69% of patients who took the supplements gained or preserved muscle mass. By contrast, only 29% of the patients receiving standard care maintained muscle mass.

The study concluded that nutritional intervention with two grams of fish oil per day provides a benefit over standard care, allowing patients to maintain their weight and muscle mass during chemotherapy.

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Source:
http://www.ncbi.nlm.nih.gov/pubmed/21360698

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If you are a diabetic and are struggling to manage your blood sugar, vitamin D can help. Previous studies have linked low serum concentrations of 25-hydroxyvitamin D [25(OH)D] with impaired glucose tolerance and diabetes. A recent clinical trial has shown that drinking yogurt with extra vitamin D may help people with diabetes regulate their blood sugar.

In the trial, 90 adults with diabetes were divided into three groups, all were given daily yogurt drinks: one group received plain yogurt, one got yogurt with extra vitamin D, and one was given yogurt with extra vitamin D and calcium.

After 12 weeks, the researchers found a remarkable improvement in the blood sugar of both group of subjects who consumed vitamin D enriched yogurt with and without calcium.

The study suggests that vitamin D intake has a positive effect on people with type 2 diabetes.

Vitamin D supplementation is good for a number of health problems, whether it is diabetes, obesity or heart diseases. Optimize your vitamin D status and stay healthy.

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Source:
The American journal of clinical nutrition

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There is substantial evidence that link low levels of vitamin D to a number of health problems including obesity, diabetes, cancer, cardiovascular diseases and autoimmune disorders. A new study in this regard has recently reported that children with low levels of vitamin D are more likely to suffer from allergies.

Researchers looked at vitamin D levels in blood samples collected from more than 3,100 children and 3,400 adults under the National Health and Nutrition Examination Survey (NHANES). One of the blood tests assessed was sensitivity to 17 different allergens.

When the resulting data was analyzed, the researchers found no association between vitamin D levels and allergies in adults. But for children and adolescents, low vitamin D levels correlated with sensitivity to 11 of the 17 allergens tested, including both environmental and food allergens.

The researchers found that kids with vitamin D levels less than 15ng/ml were 2.3 times as likely to have allergies to oak and 2.4 times as likely to be allergic to peanuts as kids with vitamin D levels of more than 30ng/ml.

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Source:
The Journal of allergy and clinical immunology

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