There is substantial evidence that link low levels of vitamin D to a number of health problems including obesity, diabetes, cancer, cardiovascular diseases and autoimmune disorders. A new study in this regard has recently reported that children with low levels of vitamin D are more likely to suffer from allergies.

Researchers looked at vitamin D levels in blood samples collected from more than 3,100 children and 3,400 adults under the National Health and Nutrition Examination Survey (NHANES). One of the blood tests assessed was sensitivity to 17 different allergens.

When the resulting data was analyzed, the researchers found no association between vitamin D levels and allergies in adults. But for children and adolescents, low vitamin D levels correlated with sensitivity to 11 of the 17 allergens tested, including both environmental and food allergens.

The researchers found that kids with vitamin D levels less than 15ng/ml were 2.3 times as likely to have allergies to oak and 2.4 times as likely to be allergic to peanuts as kids with vitamin D levels of more than 30ng/ml.

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Source:
The Journal of allergy and clinical immunology

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The broad prevalence of vitamin D deficiency in both adults and children has been associated with several skeletal and non-skeletal outcomes. Not only adults, but also children with low serum vitamin D levels are at risk for diabetes and increasing insulin resistance, according to a new study.

The study was done recently to determine the association between vitamin D levels and fasting glucose, insulin and insulin sensitivity in obese and non-obese children.

Eighty-five kids aged 4 to 18 years were involved from the local community and sleep center. Researchers measured the BMI, fasting blood glucose, insulin and 25-OH-D levels of these children, and calculated insulin resistance.

Nearly half of the children (47%) had insufficient (25 to 50 nmol/l) or deficient vitamin D (less than 25 nmol/l) levels. These children had higher fasting blood sugar levels than their counterparts with sufficient vitamin D levels.

Researchers concluded that low vitamin D levels are common in children, putting them at risk for diabetes and increasing insulin resistance.

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Source:
Archives of disease in childhood

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Most of us may be taking vitamin D supplements. Have you ever noticed which type of vitamin D does your supplement provide? Is it D2 or D3?

Already discussed in my previous posts that vitamin D3 is better than vitamin D2 due to its bioavailability. A recently published study adds more to the evidence.

The study was designed to determine whether the two vitamin D types raise 25(OH)D serum levels to the same degree, as is widely assumed. The researchers had 64 adults over age 65 take either vitamin D2 or D3 at daily doses of 1600 IU or monthly doses of 50,000 IU.

After one year of supplementation, the researchers noticed 32percent in serum concentrations of vitamin D with D3 daily, 29 percent with D3 monthly, 21 percent with D2 daily and 11 percent with D2 monthly. In addition, the absolute increase at 12 months with D3 was greater than with D2 for both daily and monthly dosing.

The study concluded that vitamin D3 is more effective than D2 at increasing circulating 25(OH)D.

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Source:
Modern medicine

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Probiotics are beneficial bacteria, often called good bacteria that aid in maintaining the balance of microorganisms in the body’s gastrointestinal tract. There are over 400 species of microorganisms in the human digestive tract, including lactobacillus and bifidobacterium.

Probiotics are rapidly becoming a popular and important tool for preserving our natural health. The basic concept behind probiotics is that our body is host to microorganisms or bacteria known as gut flora that are essential to your health. Substances containing these microbes can be taken as a way to improve our beneficial microbial population.

Enough supportive evidence is available for the use of these popular supplements for several health conditions like diarrhea, inflammatory bowel disease, H. pylori, food allergy, lactose intolerance and yeast infections. Researchers are also studying the use of probiotics to prevent or treat colon cancer.

Mixtures of probiotic bacterial strains are more effective than single strains for conditions such as irritable bowel syndrome, immune function, respiratory tract infections and Helicobacter pylori infection, say researchers of a study published in the January 2011 “European Journal of Nutrition.” This meta-analysis, a review of previously published research, found that 75 percent of studies that compared the effects of mixed probiotic strains to their components individually found the mixture more effective at relieving symptoms.

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Source:

European journal of nutrition

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Omega-3 fish oil supplementation stimulates muscle protein synthesis in older adults and may be useful for the prevention and treatment of sarcopenia, according to a new randomized, controlled trial.

Aging is associated with a progressive loss of muscle mass, medically known as sarcopenia, which increases the risks of injury and disability. One of the factors that contribute to sarcopenia is decreased protein synthesis.

The objective of this study was to evaluate the effect of omega-3 fatty acid supplementation on the rate of muscle protein synthesis in older adults. Sixteen healthy, older adults were randomly assigned to receive either omega-3 fatty acids or corn oil for 8 weeks.

By the end of the study, the authors found that corn oil supplementation showed no effect on muscle. On the other hand, omega-3 supplementation increased muscle anabolic signaling activity.

According to the authors, the exact mechanisms by which omega-3 fatty acids stimulate muscle protein synthesis is unclear, the study provides compelling evidence of an interaction of omega-3 fatty acids and protein metabolism and suggest that dietary omega-3 fatty acid supplementation could potentially provide a safe, simple, and low-cost intervention to combat sarcopenia.

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Source:
The American journal of clinical nutrition

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For decades, good bacteria or probiotics are being used in foods because of their beneficial effects for human health. The mechanism of action of probiotics is related to their ability to compete with pathogenic microorganisms in our body and to modulate our immune response. Probiotic supplements are being used successfully in gastro-intestinal disorders.

Probiotics are also beneficial for our oral health. Although only a few clinical studies have been conducted so far, the results to date suggest that probiotics could be useful in preventing and treating oral infections, including dental caries, periodontal disease and halitosis (unpleasant odors exhaled in breathing).

Studies have shown that probiotics have the potential to control dental caries in due to their inhibitory action against cariogenic streptococci. Evidence also exists on their role in periodontal disease or oral yeast infections.

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Source:
American journal of dentistry

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Autoimmune diseases are a group of chronic illnesses which are characterized by the body’s immune system attacking its own organs. Common examples of these diseases include Chron’s disease, rheumatoid arthritis, multiple sclerosis, and ulcerative colitis. More than 75 percent of cases occur in women.

Abnormal autoimmunity affects the entire body and sometimes it can be devastating. In my previous blog, you read about an autoimmune disorder rheumatoid arthritis and its complication, heart attack. In addition, it is also known now that autoimmune diseases can also lead to miscarriage in pregnant women.

According to a new research recently published in the medical journal Autoimmunity Reviews, there is evidence that maternal autoimmunity can cause genetic abnormalities in embryos. These genetic problems are considered to account for about 60% of all miscarriages.

The study determined that maternal autoimmunity itself can increase the risk of genetic abnormalities in embryos. Study authors are encouraging doctors to test women who experience recurrent pregnancy losses for autoimmune diseases as a way to better prevent miscarriages.

There is substantial evidence available which also shows that vitamin D deficiency contributes to autoimmune disease. Vitamin D is a powerful immunomodulator and its effect has already been shown in the prevention and treatment of some autoimmune diseases.

Discuss with your healthcare provider to learn how optimal Vitamin D levels can improve your over all health especially with regards to auto-immune disorders.

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Source:
Autoimmunity Reviews

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Rheumatoid arthritis (RA) is an autoimmune disorder that leads to inflammation of the joints and surrounding tissues. Normally, the body’s immune system normally fights off foreign substances, like viruses. But in an autoimmune disease, the immune system confuses healthy tissue for foreign substances. As a result, the body attacks itself.

Autoimmune diseases can also affect other organs. There is evidence also that patients with rheumatoid arthritis are more apt to heart diseases.

According to a study published in the December 2010 issue of the Journal of Internal Medicine, there is a 60% increased risk of having a heart attack in patients diagnosed with RA compared to those without RA.

Swedish researchers followed 7,469 patients diagnosed with RA between 1995 and 2006, together with 37,024 matched controls without RA to determine the risk of ischemic heart disease, with particular reference to myocardial infarction (heart attack).  It was found that the risk of an acute heart attack in RA patients rose by 60% in one to four years after diagnosis. The researchers also found that having RA increased the risk of any ischemic heart disease by 50%.

It has been known for years that vitamin D is a powerful immune modulator. The positive effect of vitamin D supplements is shown in many autoimmune disorders including rheumatoid arthritis. Adding a vitamin D3 supplement will surely help you improve your vitamin D levels and enjoy related immunomodulatory benefits.

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Source:
Journal of internal medicine

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It has been estimated that 1 in 10 of US population have prediabetes and prehypertension which often have other risk factors too, and therefore are at greatly increase risk for stroke and heart attack. Prehypertension and prediabetes, two most common culprits of cardiovascular risk, may be an outcome of vitamin D insufficiency, a recent study suggests.

If your fasting blood sugar is between 100-125 mg/dL, you are in a prediabetic stage. If systolic BP is 120-139 and/or diastolic BP is 80-89 mmHg, the condition is referred to as prehypertension. These conditions should be identified timely so as to take appropriate steps and lower the cardiovascular risk.

Healthy adults included in the National Health and Nutrition Examination Survey of 2001 to 2006 were assessed.  Those with fasting blood sugars of 100 to 125 mg/dL (5.5 to 6.9 mmol/L), and systolic (top number) blood pressures of 120 to 139 and diastolic blood pressures (bottom number) of 80 to 89 were considered prediabetic or prehypertensive and their vitamin D levels were obtained.

People who were prediabetic and/or prehypertensive were found to be more than twice as likely to have low levels of vitamin D rather than normal levels.

Many of us may have prediabetes or prehypertension. Generally, these conditions are asymptomtic. It is most likely that you may have low vitamin D levels. Get your vitamin D level tested and take vitamin D supplements if they are on the lower side.

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Source:
Diabetes care, Jan 2011

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An under active thyroid, also called hypothyroidism, may result in weight gain, fatigue, extreme cold, and increased menstrual periods in women. When the thyroid gland’s activity increases beyond normal, a condition called hyperthyroidism develops. Symptoms include pounding heartbeat, extreme anxiety, rapid weight loss and raised temperature.

While several factors may result in either condition, the most common causes are autoimmune diseases called Graves’s disease or autoimmune hyperthyroidism and Hashimoto’s thyroiditis or autoimmune hypothyroidism (AITDs).

An autoimmune disease is a disease in which the body’s immune system, which normally protects against invaders such as viruses and bacteria, becomes confused and attacks healthy tissue. In this case, the immune system attacks the thyroid gland, causing it to malfunction.

Vitamin D has been linked to various autoimmune disorders such as rheumatoid arthritis, inflammatory bowel disease, asthma and multiple sclerosis. Recent studies have also linked it to autoimmune thyroid diseases.

Recently, a study was undertaken to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy controls. Serum vitamin D (25-OH) levels were measured in 50 patients with AITDs, 42 patients with non-AITDs and 98 healthy subjects. Vitamin D deficiency was designated at levels lower than 10 ng/ml.

Results showed that vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals (72% versus 30.6%), as well as in patients with Hashimoto’s thyroiditis compared to patients with non-AITDs (79% versus 52%). Vitamin D deficiency also correlated to the presence of antithyroid antibodies and abnormal thyroid function tests.

The study suggests the involvement of vitamin D in the pathogenesis of AITDs and advises vitamin D supplementation.

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Source:
Cellular and molecular immunology

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